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Bayesian optimization algorithms should guide the experimental parameter space exploration, using physically-constrained objective functions that prioritize pore size distributions (mesopore ratio 0.30.6) and heteroatom ratios (N/S 48, O 815 at%) derived from the design principles

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Growth hormone is the main example

doi: 10.1210/jc.2010-0490

Vlasova TI, Stratton SL, Wells AM, Mock NI, Mock DM

This is the most popular reconstitution volume among experienced researchers who have moved past the initial titration phase