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SURMOUNT-2, which included participants with type 2 diabetes, showed weight reductions of 12.8% to 15.7% with tirzepatide versus 3.2% with placebo
Patients with specific GLP1R or GIPR variants show greater sensitivity to dose reductions and benefit from 8-12 week weaning rather than 6 weeks
The most effective FDA-approved options for weight loss are tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic)
Drug interactions Do not use LDN with opioid medications, opioid-containing cough suppressants, or medications that contain opioids of any kind LDN will block their effects and can precipitate withdrawal in opioid-dependent individuals
The risks, side effects, and cost are not worth it for small weight goals
To optimize the results of semaglutide GLP-1, it is recommended to combine the medication with a reduced-calorie diet and regular exercise
