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However, achievements of incretin-based therapies are often tempered by the need to maintain lifestyle changes and by gastrointestinal disturbances that compromise dose escalation, tolerability and adherence, indicating challenges for the design of future agents
Wegovys active ingredient, semaglutide, works by mimicking the natural hormone GLP-1, which is crucial for regulating appetite, blood sugar levels, and insulin release
DPP-4 inhibitors are oral medications that may be considered when type 2 diabetes needs more support, when another drug is not tolerated, or when a treatment plan needs to stay simple
From a GRADE perspective, the certainty of evidence was rated as high for efpeglenatides renal composite benefit (large, blinded CVOT with consistent effects)
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