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In plain terms, possible symptoms include nausea diarrhea vomiting constipation

Studies have shown that tamoxifen resistance is associated with IGFBP-1 accumulation and that the overexpression of IGFBP-1 promotes tamoxifen resistance in breast cancer cells by activating the ERK pathway, which can be reversed by knocking down IGFBP-1 (134)

This shift in perspective has led to a change in the focus of research toward populations in the prodromal or preclinical stage with positive results for diagnostic biomarkers

In one of these studies, Mishra et al

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The observation was further confirmed by flow cytometry (Fig