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Patients initiating GLP-1 therapy for diabetes or weight management who also experience joint pain should maintain a comprehensive approach to musculoskeletal health
They reported that LGMSCs and their derived Exos decrease inflammatory cells infiltration to salivary glands and reserve their secretory function in non-obese diabetic (NOD) mice, raise regulatory T cells proliferation and inhibit T helper-cell 17 differentiation in NOD mice and SS patients invitro with increase Tcell secretions of IL-10 and transforming growth factor beta(TGF-) and decreased cytokine levels(IL-6, IL-17, Interferon-gamma) (85)
Must be documented and prescribed through a legitimate registered pharmacy
These patients had been diabetic for about 2.5 years and only about 15% of patients had ever been on a medication to treat their diabetes, these were truly treatment naive patients
Le-Vel likely recommends continuous use to maintain sales, but cycling off periodically might prevent tolerance while saving money
Sanofi developed Toujeo as the next generation of their insulin glargine line
