Without validated biomarkers of efficacy, real-world results remain anecdotal at best
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A high-fat diet induces the expression of the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mhMGCs) in jejunal tissue and the production of functional ketones, which act on the fatty acid/ketone receptor FFAR3 expressed in the small intestinal epithelium to inhibit GLP-1 secretion (42)
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Individuals with cerebral folate deficiency have been observed to have developmental delays with autistic features (e.g., challenges with social communication, sensory processing, and repetitive behaviors), seizures, and problems with movement and coordination
The company is leveraging its diagnostics and digital health expertise to create integrated metabolic disease management solutions around GLP-1 therapies