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Biomolecular mechanism of urinary stone formation involving osteopontin

Malic enzymes ME participate in reactions that link the components of catabolic metabolism in glycolysis and the Krebs cycle via the oxidative decarboxylation of malate to pyruvate, thereby inducing the anabolic metabolism with concomitant NADPH production

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This explains why triggers that caused no problems during remission can suddenly spark a flare-up