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Funding This work was supported by a R01MH128311 and a R56MH125895 to CN

This observation suggests that abnormal EAT mass may act as a driving factor in the early pathophysiological process of AF rather than a concomitant consequence of late LA structural remodeling (characterized by increased LA volume) (82)

A further approved T2D GLP-1 mimetic peptide, lixisenatide, shares a common first 37 amino acids with exendin-4, including most of the GAPPPS sequence, but includes an additional six lysine residues at the C-terminus prior to the terminal amidation (Andersen et al., 2018)

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The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration