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To mitigate these effects, the trial utilized a step-wise titration approach, starting patients at 2 mg once weekly and increasing the dose every 4 weeks until reaching target levels of 4 mg, 9 mg, or 12 mg
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activation of adhesion molecules VCAM-1, MCP-1, E-selectin and ICAM-1
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Someone experiencing anhedonia may notice that: Food no longer feels enjoyable Hobbies feel flat or pointless Socialising feels less rewarding Relationships feel harder to engage with Motivation has noticeably fallen Life feels emotionally muted The important distinction is how widely that loss of interest extends
