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A histological analysis showed that the drug not only increased the number and area of mitochondria, but also increased the ratio of type I/type II muscle fibers, total muscle fiber area, and muscle fiber density [28]

Of note, neuroinflammation has furthermore been implicated in the pathophysiology of depression [87], whereas increased inflammatory markers, such as C-reactive protein (CRP) or interleukin-2 (IL-2), have been specifically described to be more associated with the atypical subtype of depression [69]

Outcome measures include neurological severity scoring, rotarod and beam walk performance, histological assessment of lesion volume, and immunohistochemistry for axonal markers and myelin basic protein