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People at Risk The risk of adverse effects is especially high in people with [70+]: Digestive conditions (Crohns disease, ulcerative colitis, diverticulitis) A history of bowel surgery Severe hemorrhoids Kidney, heart, and liver disease Allergy to coffee The FDA only approves colon cleansing to prepare for medical procedures and has issued several letters warning about unapproved uses

Xanthurenic acid, the major downstream metabolite of 3-HK capable of crossing the BBB, exhibits both antioxidant and pro-oxidant properties depending on experimental context [158, 161,162,163]

It is commonly suggested to help the body generate energy at a cellular level, especially when normal diet and nutrient levels fall short

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From 1 mg, increase to 2 mg