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In the main trial approximately 47% of participants discontinued treatment due to adverse events, depending on the dose, with higher doses linked to increased discontinuation
Available at: Lamija Ferhatbegovi, Mri, D
Since all the fragments crystallized in subpocket C contained HEPE moiety with an additional polar substituent, it was tempting to think that a similar polar moiety should be placed in subpocket C
Suggested Weekly Dosage Schedule* Weeks 14: 2 mg (0.20 ml) once a week
It is used to treat deficiency of vitamin B12 in the body
a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged
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