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NEJM (May 2025) Bottom Line: This multicenter, open-label, noninferiority trial evaluated the efficacy and safety of methotrexate compared to prednisone in treating pulmonary sarcoidosis in 138 patients who had not previously received treatment

GAPDH (glyceraldehyde 3-phosphate dehydrogenase) served as a loading control for total protein, while Histone-H3 was used for nuclear extracts

They can suggest an adjustment to the dosage or timing of the drug or potentially recommend an alternative drug

Leptin resistance, disrupted hunger signaling, altered gut microbiome composition, and genetic predisposition all play documented roles

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