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Gastroenterology 132:21312157 Doyle ME, Egan JM (2007) Mechanisms of action of glucagon-like peptide 1 in the pancreas

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The inactive structure of GLP-1R presented here aligns nicely with a possible role of the GLP-1R ECD as a negative regulator of GLP-1R, although, in contrast to GCGR, we and others have failed to identify mutations in the ECD/ECL interface that increase basal activity of GLP-1R

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This hormone helps delay stomach emptying, decreases hunger signals to the brain, and aids in maintaining stable blood sugar levels