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Happens in less than 2% of cases

Human studies indicate that the insulinotropic action of GIP is blunted in individuals with severe hyperglycemia, in contrast to the intact action of GLP-1

If a patient reports side effects, record them in the clinical note with time of onset, severity, and duration

Long-Term Results and Maintenance As you move past the first few months, the benefits of peptide therapy become more established

GLP1-R reduces liver fat content, improves hepatic insulin sensitivity, and decreases inflammatory cytokines

These medications also carry a boxed warning about thyroid C-cell tumors observed in rodent studies