side effects switching from semaglutide to tirzepatide Semaglutide and #tirzepatide have improved

Li J, Yuan T, Zhao X, Lv GY, Liu HQ

A study published in the journal Diabetes, Obesity and Metabolism found that patients on once-weekly semaglutide experienced significant decreases in serum B12 levels alongside reductions in zinc and albumin

26 Experiments in pancreatic islets reveal that -arrestin limits the insulin response to GLP-1, but not GIP or tirzepatide, suggesting that the biased agonism and imbalance of tirzepatide toward the GIP receptor and its unique GLP-1 receptor signaling properties might be at the basis of its potent action

Cancer Cell (2015) 27(2):21122

However, the FDA didnt add ileus (lack of proper intestinal movement or function) to Ozempics and Wegovys warning labels until 2023

IL-17A directly downregulates the expression of tight junction proteins including ZO-1 and claudin-1 via the ERK/STAT3 signaling axis