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Generally, patients receiving consistent injections report improved quality of life
However, functional deficiency can exist at levels up to 350 pg/mL, particularly when methylmalonic acid is also elevated
NICE has approved semaglutide (TA875) and liraglutide (TA664) for managing overweight and obesity in specific patient groups within specialist services, subject to prescribing criteria and monitoring requirements
(variable)
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The practical evidence remains limited
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