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Primary outcomes measured safety through AEs monitoring, anti-drug antibody development, immune cell biomarker changes via flow cytometry, T-cell proliferation assays, and cytokine production in peripheral blood mononuclear cells, while secondary outcomes included clinical response using MS and endoscopic assessment
There were no significant correlations between metabolite component scores and antipsychotic dose in either patient group, nor were there significant correlations with age
As shown in FIGURE 11, the model fits reasonably well, consistent with the proportional negative-feedback control model
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These effects were coupled to an amelioration in lipid metabolism and hepatic steatosis, which markedly exceeded the effect of single GLP-1RA treatment (72)
Tirzepatide is an FDA-approved weight loss medication that functions as a dual-action GLP-1/GIP receptor agonist
