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Because GHK-Cu relies on signaling rather than chemically exfoliating the skin, it takes time for the collagen cycle to turn over

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Increased p53 protein levels have been observed in the neuronal cells of brain tissues from NDD patients and animal models

This is mechanistically distinct from proton pump inhibitor pharmacology and is part of why the peptide attracts interest as a research tool for ulcer biology and NSAID-induced gastric injury

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Start Slow: Begin with 10-15 minutes at 130-150F , gradually increasing time and temperature as tolerated