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Consenting adults donated blood samples for DNA extraction, underwent anthropometric, blood pressure and resting heart rate measurement, and provided extensive information on demographic characteristics, genealogy, education, occupation and lifestyle, as well as health status and medical history 70

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Recently Novo Nordisk announced the acquisition of INV-202, an oral CB1 inverse agonist designed to preferentially block CB1R in peripheral tissues

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First it is difficult for GLP-1 agonists to achieve anti-fibrosis effects because the major effect of GLP-1 agonists on MASH is likely to be indirect by extrahepatic path. Second, semaglutide has been shown to be ineffective in patients with compensated MASH-related cirrhosis10