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33 Consistent with this concept, in vivo zebrafish injury models have demonstrated that lipid peroxidation can act as a spatial redox relay over hundreds of micrometers, providing a biologically relevant framework for how oxidative signals may propagate across multicellular tissues
This action leads to closure of glucose-dependent ATP-sensitive K + channels which depolarizes the cell and thereby opens voltage dependent Ca 2+ channels allowing Ca 2+ influx which stimulates insulin secretion
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OKeefe J et al
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