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348 Hypertension control

While GLP-1 analogs for treatment of type 2 diabetes cause mild-to-moderate nausea and vomiting in a significant proportion of patients, their benefits in terms of weight loss and improved glycemic control have allowed the class to overcome these tolerability concerns and become one of the most-prescribed classes of type 2 diabetes medications in the US and Europe (326)

The plasmid DNA encapsulated by LNPs demonstrated optimal characteristics for liver targeting, including particle size of approximately 100 nm, low polydispersity (approximately 0.2), neutral surface charges, and high DNA encapsulation efficiency (Supplementary Table 4) 25

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