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Exenatide has a subtle yet prolonged effect to reduce appetite, promote satiety via hypothalamic receptors (different receptors than for amylin)

doi: 10.1007/s00125-002-1028-x 19 SchirraJNicolausMWoerleHJStruckmeierCKatschinskiMGkeBet al

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Insulin resistance causes fatty liver, and fatty liver worsens insulin resistance