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Zhou et al., 2021), which may significantly enhance the activities of MMPs and pathological remodeling of the vessel wall (Wang and Khalil, 2018), subsequently resulting in obstruction and ischemia

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Research uses MT-1 to establish the reference pharmacodynamic profile for MC1R activation , characterising concentration-response relationships, receptor internalisation kinetics, and downstream melanin synthesis biology that serve as the benchmark for evaluating other melanocortin agonists and antagonists at MC1R