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[3] Patients with pre-existing diabetic retinopathy should be monitored for worsening when glycaemic control improves rapidly, as noted in the SmPC

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However, because DPP-IV ubiquitously degrades important regulatory peptides in addition to GLP-1 [33], the use of a DPP-IV inhibitor might theoretically cause widespread deleterious biological effects

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Multiple molecular subtypes of GST have shown the ability to prevent skin, colon, and liver cancer initiation in mice exposed to carcinogens or lacking tumor suppressors (Van Remmen et al., 2003)

From what Ive seen coaching clients on similar protocols: Prioritizing heavy compound lifts (squats, deads, presses) 34x/week Hitting protein targets every day Keeping some calorie deficit but not extreme helps shift the ratio toward fat loss while preserving (or even building) muscle