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The Bottom Line: How Long Does It Take to Lose Weight on Semaglutide Most people begin losing weight on semaglutide within 24 weeks, with more consistent and noticeable weight loss after 812 weeks

( 1 ) This multi-layered mechanism helps explain why GLP-1s are being used beyond people with diabetes

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Medicaid state agencies can join the BALANCE Model beginning in May 2026 and Part D plan sponsors can opt into the model beginning in January 2027

Its value lies in expanding options, reaching people who may respond differently to different pathways, and advancing the science of combination-based approaches