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The limitation: copper peptides are relatively large molecules and don't penetrate as deeply as small molecules like minoxidil

Ex-9 injected into the NTS blocked the reducing effect of systematic Ex-4 on locomotor activity in mice (Vallf et al., Nicotine Ex-4, at doses not affecting baseline locomotor activity, reduced nicotine-induced locomotor behavior, accumbal dopamine release, and blocked nicotine-induced CPP in mice

That might not sound like a lot, but for me, it was huge

Nat Cell Biol (2023) 25:526-27