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Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D

In the recently published BARI-OPTIMISE double-blind, placebo-controlled trial, 70 patients post-SG or RYGB who were tested and found to have insufficient GLP-1 response to meal stimulation were randomized to receive liraglutide (3 mg/day) or placebo, in addition to lifestyle interventions [49]

Among them, several genes seemed to be involved in mitochondrial metabolism and oxidative stress, as e.g., SLC25A39

This suggested that the gut must secrete an insulin-stimulating substance in response to meals

National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center