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However, unlike SGLT-2 inhibitors and GLP-1 receptor agonists, they have not demonstrated significant cardiovascular or renal protective benefits beyond glucose lowering, which is an important consideration in patients with established cardiovascular disease

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A separate category, including CJC-1295 and Sermorelin, works through growth-hormone stimulation instead of appetite signaling: these peptides prompt the pituitary gland to release more of the body's own growth hormone, which supports fat metabolism and helps preserve lean muscle during a calorie deficit

GLP-1 receptor agonists are a class of medications that mimic the glucagon-like peptide-1 hormone, enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying to lower blood glucose levels