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According to the SUSTAIN trials, this usually resolves on its own, but bland, low-fibre meals and proper hydration can help manage it in the short term
Semaglutide also reduces hunger signals and increases feelings of fullness
You can read the abstract of this article at In the SURPASS-4 trial, the dual GIP and GLP-1 receptor agonist tirzepatide demonstrated superior reductions in HbA1c concentrations, bodyweight, and blood pressure compared to titrated daily insulin glargine in individuals with type 2 diabetes and cardiovascular risk
The daily dosing requires daily commitment
However, a randomized controlled trial that compared once-a-week 2.4 mg of semaglutide to placebo in type 2 diabetes patients found that 67.5% of participants had an HbA1c lower than 48 mmol/mol (6.5%) at the end of 68 weeks
Not without clinician guidance
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