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In a trial involving 74 patients comparing vitamin B12 supplementation with 500 g/day versus 1500 g/day after 3 months of treatment, 8% of those on the lower dose had deficient levels versus none on the higher dose (17)

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They contain the active ingredient norethisterone , which can also be found under the brand name Utovlan

5 Endocrinology, Diabetology and Medical Andrology Unit, IRCCS, Humanitas Research Hospital, Milan, 20089, Italy Correspondence: Alessandra Di Maria, Department of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, Milan, 20089, Italy, Tel +39 02 8224 2555, Email [email protected] Purpose: Dry eye disease (DED) is a prevalent ocular surface disorder frequently associated with type 2 diabetes mellitus (T2DM)