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A case series suggests that treatment with the incretin-based agents semaglutide and tirzepatide may trigger dysesthesia or allodynia in some individuals
Similar content being viewed by others Subjects Introduction From 2000 to 2019, the Global Burden of Disease study showed a 0.48% annual increase in age-standardized disability-adjusted life years (DALYs) related to obesity, defined as a body mass index (BMI) 25 kg/m 2 1
Archives of Physical Medicine and Rehabilitation
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It was the first large, rigorous head-to-head study between these two medications and was published in the New England Journal of Medicine in May 2025
But long-term success depends on more than access to medicationit hinges on how well a program supports behavior change, eating psychology, and maintenance over time
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