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Discard the medication if it becomes cloudy or contains particles

doi: 10.1166/jbn.2023.3720 183 FangWXieSDengW

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Generation of 5,6,7,8-tetrahydronaphthalene-2,3-diol To a pressure tube dried overnight at 150 C in a drying oven was added under inert gas 2,3-dihydroxy-naphthalene (0.162 g, 1.01 mmol, 1.0 eq.), [Rh(cod)Cl]2 (75.0 mg, 0.015 mmol, 1.0 eq., 15 mol%) and polymethylhydrosiloxane (0.18 ml, 3.00 mmol, 3.0 eq.) in methanol (3 ml)

The result at week 68: Continued semaglutide 2.4 mg: lost an additional 7.9% of body weight (total loss from baseline: 17.4%) Switched to placebo: regained 6.9% of body weight (net loss from baseline: 5.0%) Thats a roughly 15-point difference in body weight between the two groups at the end of the trial, attributable entirely to whether the medication continued

Tohyama M, Shirakata Y, Hanakawa Y, Dai X, Shiraishi K, Murakami M, et al