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Vitamin B12 (also known as cobalamin) is a water-soluble vitamin that plays a key role in: Normal red blood cell formation Normal energy-yielding metabolism Function of the nervous system Reduction of tiredness and fatigue DNA synthesis Normal psychological function In the UK, these are recognised health claims for vitamin B12 under authorised nutrition and health regulations
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There are two possible causes of a vitamin B12 deficiency: inadequate intake, or inability to absorb it into the body
29 Due to its importance in the synthesis of myelin and neurotransmitters, as well as in keeping homocysteine levels low, all of which are associated with cognitive function, B12 has been studied for a potential role in cognitive function
Cobalamin deficiency should not be assumed to be due to pernicious anemia (ie, autoimmune destruction of parietal cells resulting in intrinsic factor deficiency) simply because that is the most common cause
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