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Individuals who used GLP-1RAs for 0.5, 1, and 1.5 years had IRRs close to 1.0, with no significant decrease in MACE risk at three years, although these estimates varied across specific treatment strategies defined by prior duration and subsequent exposure patterns
Moreover, AMPK plays a pivotal role in regulating cholesterol concentrations by upregulating ATP-binding cassette (ABC) transporters (e.g., ABCA1 and ABCG1), downregulating the expression of cholesterol synthesis gene 3-hydroxy-3-methylglutaryl-coenzyme A reductase ( HMGCR ), inhibiting SREBP - 1, suppressing the mTORC1 pathway, and mitigating plaque formation (6871)
& Giugliano, D
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