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Comment on Rossing et al

Semaglutide dosage is designed to gradually increase over time to minimize side effects

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This selectivity is particularly important for individuals seeking pure fat reduction rather than body recomposition, those who do not want muscle hypertrophy for aesthetic or functional reasons, athletes in weight-class sports who need fat loss without muscle gain, individuals with contraindications to growth-promoting interventions, and those concerned about cell proliferation effects

A total of 1961 adults with a body-mass index (BMI) of 30 or above (or 27 in individuals with at least one weight-related medical condition) and without diabetes were enrolled in the study