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DOI: 10.1016/j.fct.2020.111521

in tandem with other human factors such as the human leukocyte antigen (HLA), epigenetics, preexisting comorbidities (i.e., T2DM, CVD, obesity), age, preceding systemic impairments (i.e., hyperinflammation, micro-thrombosis, fibrosis, dysbiosis, autoimmunity, etc.), and socio-demographic factors (i.e., food security, environment, access to medical care) 22,27,28

(PubMed) Mills JL

[171] According to a 2025 review, the discontinuation of amphetamine at therapeutic doses does not typically result in withdrawal symptoms

However, long-term usage of such medications is associated with severe adverse effects and complications