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A buildup of ROS such as H 2 O 2 (hydrogen peroxide) and O 2 - (superoxide anion) can lead to changes in metal homeostasis or oxidation states of protein metal complexes, such as the release of Fe from ferratin or the reduction of iron in cytochrome C [119]

In particular, multiple mouse DAO genes were upregulated in CIL and/or RL lesions, including SOCS3, CDKN1A, FOS, JUNB , and GADD45A/B (Supplementary Fig

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Combination t herapies and e xpanding i ndications Combination therapy often results in synergistic effects, with benefits that surpass the sum of individual treatments

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