This dose is the highest dose meeting tolerability and safety criteria in the phase I study of (in)GSH in PD
[66] The beverage has initial numbing and astringent effect in the mouth caused by the local anesthetic action of kavalactones and chewing it has local anesthetic effects similar to that of cocaine and longer lasting than benzocaine
Evidence from studies ranks avocado among the top fruit sources of glutathione
456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields
However, IV vitamin C takes a long time to work, so if there is a possibility that the patient will need treatment, it may make sense to initiate therapy with IV vitamin C sooner rather than later
Safety Considerations Glutathione is generally considered safe for most people when taken as a supplement