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Both GLP-1 signaling and mTOR modulation have been shown independently to support endothelial function, reduce vascular inflammation, and improve barrier integrity in preclinical models

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Ileus and intestinal blockage: Obstruction in the intestines that can cause severe pain and require surgical intervention

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Large-scale clinical trials and meta-analyses show no increased overall cancer risk with GLP-1 medicines compared to placebo or other diabetes treatments