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An overview of systematic reviews in the journal Nutrients by Wang and colleagues took a harder look at the same question, examining six reviews covering 75 trials

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Endocrinology 149 , 56795687, (2008)

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110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis