Studies in Expert Opinion on Drug Delivery reveal intranasal delivery typically achieves a bioavailability of less than 5% in humans for most peptides
Links to external content or practitioners are provided for convenience only
Blocks the NNMT enzyme that converts nicotinamide to N-methylnicotinamide, preserving nicotinamide for NAD+ synthesis and cellular energy pathways
We also recommend a balanced diet full of fruit and vegetables, particularly sulfur-rich foods such as broccoli, kale, mushrooms, egg, meat, fish, garlic, and onions
A similar protection against steatosis has been previously noted in GCLM KO mice challenged with other liver toxicants 38 or stress-inducing diets 17,39
250500mcg may be a good starting dose, with the same five days on and two days off approach, which might be something people with inflammation issues want to consider