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If gastrointestinal symptoms become severe, temporarily returning to the last tolerated dose followed by more gradual re-escalation may be appropriate

This huge adherence gap means that real-world effectiveness falls far short of trial efficacy

Plutzky reports consulting fees from Altimmune, Amgen, Boehringer Ingelheim, Esperion Therapeutics, Merck, MJH Life Sciences, Novartis, and Novo Nordisk, as well as institutional grants from Boehringer Ingelheim and Novartis.

NICE obesity guidance is clear about who qualifies and under what circumstances

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

Reconstitution and storage requirements differ between compounds