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Knockout of either Grx5 or Grx3 leads to iron accumulation in cells [31,136,137] , impaired FeS cluster biosynthesis [138] , and deregulated iron homeostasis via IRPs [31,137,139] (Figure 4)

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The side effects are mostly in the Gastrointestinal area: Nausea and vomiting Diarrhea or constipation Abdominal pain Dizziness, Tachycardia, Infections, Headaches being lesser reported

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