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Creatine supplementation has been shown to down-regulate the synthesis of l-arginine : glycine amidinotransferase and consequently reduce endogenous formation of creatine, changing the methylation flux and reducing Hcy synthesis ( Reference Taes, Delanghe and De Vriese 6 , Reference Stead, Au and Jacobs 20 )
Lee HB, Ha H, Kim SI, Ziyadeh FN
PMID: 15817669 | doi:10.1210/en.2004-1286 Teichman SL et al
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