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Both receptors couple to Gs proteins and activate adenylyl cyclase, raising intracellular cAMP in beta cells and triggering insulin exocytosis in a glucose-dependent manner

Tesamorelin acts through GHRH receptor signaling, while ipamorelin targets ghrelin (GHS-R1a) pathways, supporting complementary stimulation of pulsatile GH release

Patients with personal or family history of medullary thyroid carcinoma should not use these drugs

Both are proven prescription medications that not only help regulate blood sugar but can also assist with weight management for eligible patients

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M., Bsselberg, D., Kubatka, P., & Shakibaei, M