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Sodium Hydroxide and/or Hydrochloric Acid may have been used to adjust pH

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however, the residual amount of one of these lines fluctuated abnormally from 1% in the 1st generation to 53% in the 36th generation and then decreased to 1% in the 59th generation

When combined with tirzepatide, which improves insulin sensitivity, the net effect is likely neutral or positive, but this has not been formally studied