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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

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This includes eating a balanced diet, staying hydrated, getting regular exercise, and managing stress

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Many people start with one and consider switching between the two , so understanding both dosage frameworks helps you make informed decisions with your prescriber