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Overall, current evidence suggests that combination therapy is biologically plausible and clinically promising, but definitive conclusions regarding incremental benefit in established HF await dedicated randomized outcome trials

There are no strict restrictions, but its best to limit high-fat and sugary foods that can worsen side effects like nausea

Hamilton adds that this can create a tired appearance, thin the skin and accentuate dark circles

Dehydration, which can occur with gastrointestinal side effects such as vomiting or diarrhoea, may also contribute to joint discomfort

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