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Global pharma companies must navigate both: they usually offer the lowest net price in the UK (NICEs domain) while keeping the U.S

These findings are observational, meaning they cant concretely prove a cause-and-effect link between chronic cough and GLP-1 use

According to the MHRA SmPC, these include: Nausea : very common (may affect more than 1 in 10 people) Vomiting and diarrhoea : common (may affect up to 1 in 10 people) Constipation : common, potentially related to delayed gastric emptying Abdominal pain and dyspepsia : common These gastrointestinal effects generally diminish over time as the body adapts to the medication

[ref] Mutations in the CFTR gene that cause cystic fibrosis can also cause pancreatitis

While generally regarded as safe for short-term use in healthy individuals, the long-term safety of routine digestive enzyme supplementation in patients on GLP-1 therapy has not been systematically evaluated

We think so